SREBP1 antibody
GTX79299
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetSrebf1
Overview
- SupplierGeneTex
- Product NameSREBP1 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:5000. ICC/IF: 1:50-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID20787
- Target nameSrebf1
- Target descriptionsterol regulatory element binding transcription factor 1
- Target synonymsADD-; ADD1; adipocyte determination- and differentiation-dependent factor 1; bHLHd; bHLHd1; SRE; SREB; SREBP; SREBP1; sterol regulatory element-binding protein 1
- HostRabbit
- IsotypeIgG
- Protein IDQ9WTN3
- Protein NameSterol regulatory element-binding protein 1
- Scientific DescriptionThis gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. Alternatively spliced transcript variants have been characterized for this gene. [provided by RefSeq, Nov 2017]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Partial Replacement of Diet with Dehulled Adlay Ameliorates Hepatic Steatosis, Inflammation, Oxidative Stress, and Gut Dysbiosis in Rats with Nonalcoholic Fatty Liver Disease.Read more
- 15-keto-PGE(2) alleviates nonalcoholic steatohepatitis through its covalent modification of NF-kappaB factors.Read more
- Caulerpa lentillifera improves ethanol-induced liver injury and modulates the gut microbiota in rats.Read more
- Therapeutic Effect of Curcumin on 5/6Nx Hypertriglyceridemia: Association with the Improvement of Renal Mitochondrial beta-Oxidation and Lipid Metabolism in Kidney and Liver.Read more
- Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet. Garcia-Arroyo FE et al., 2021 Feb 28, Int J Mol SciRead more
- Hylocereus polyrhizus Peel Extract Retards Alcoholic Liver Disease Progression by Modulating Oxidative Stress and Inflammatory Responses in C57BL/6 Mice. Yeh WJ et al., 2020 Dec 18, NutrientsRead more
- Helminthostachys zeylanica alleviates hepatic steatosis and insulin resistance in diet-induced obese mice. Chang TC et al., 2019 Dec 13, BMC Complement Altern MedRead more
- Allopurinol Prevents the Lipogenic Response Induced by an Acute Oral Fructose Challenge in Short-Term Fructose Fed Rats. Garcia-Arroyo FE et al., 2019 Oct 11, BiomoleculesRead more
- Antroquinonol Attenuated Abdominal and Hepatic Fat Accumulation in Rats Fed an Obesogenic Diet. Chen JR et al., 2019 Sep, J Food SciRead more
- Clinical importance of FASN in relation to HIF-1alpha and SREBP-1c in gastric adenocarcinoma. Ezzeddini R et al., 2019 May 1, Life SciRead more