SREBP2(SREBP2/1579), CF405S conjugate, 0.1mg/mL [26628-22-8]

Biotium

SREBP2(SREBP2/1579), CF405S conjugate, 0.1mg/mL

9

Research Use Only

Monoclonal

SREBP2/1579

0.1 mg/ml

Other Conjugate

SREBF2

sterol regulatory element binding transcription factor 2

bHLHd2; class D basic helix-loop-helix protein 2; SREBP2; SREBP-2; sterol regulatory element-binding protein 2

Mouse

IgG1

Sterol regulatory element-binding protein 2

The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a ten base pair sequence in the 5 flanking region, designated sterol regulatory element 1 (SRE-1). When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SREbinding proteins (SREBPs) have been identified, including two basic helixloop-helix-leucine zipper (bHLH-zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Bovine, Human, Mouse

2°C to 8°C

12352203