SRI-29574 [1928712-46-2]

TargetMol Chemicals

SRI-29574 [1928712-46-2]

9

Research Use Only

C29H23N5

441.53

SRI-29574 acts as an allosteric modulator of the dopamine transporter (DAT), partially inhibiting its uptake (IC50=2.3 nM) while also moderately inhibiting the uptake of serotonin transporter (SERT) and norepinephrine transporter (NET). This compound serves as a valuable probe for researching the function and regulatory mechanisms of DAT.

N=1C=CN2C=C(C=CC12)C3=NC=4C=CC=CC4C(=N3)NCC(C=5C=CC=CC5)C=6C=CC=CC6

-20°C

12352200