SRT1720 Hydrochloride [1001645-58-4]

Mitchell SJ, Martin-Montalvo A, Mercken EM, et al. The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet. Cell Rep. 2014 Mar 13;6(5):836-43. PMID: 24582957. Cao L, Liu C, Wang F, et al. SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-kappaB pathway. Braz J Med Biol Res. 2013 Aug;46(8):659-69. PMID: 24036938. Nguyen GT, Schaefer S, Gertz M, et al. Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanism. Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1423-32. PMID: 23897466. Fan H, Yang HC, You L, et al. The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury. Kidney Int. 2013 Mar;83(3):404-13. PMID: 23302720. Suzuki K, Hayashi R, Ichikawa T, et al. SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice. Oncol Rep. 2012 Jun;27(6):1726-32. PMID: 22470132.