ST3gal6 antibody

GeneTex

ST3gal6 antibody

9

WB: 1 - 2 microg/mL. ICC/IF: 5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

ST3GAL6

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

alpha2,3-sialyltransferase ST3Gal VI; CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI; sialyltransferase 10 (alpha-2,3-sialyltransferase VI); SIAT10; ST3GALVI; type 2 lactosamine alpha-2,3-sialyltransferase

Rabbit

IgG

Type 2 lactosamine alpha-2,3-sialyltransferase

Sialyltransferases catalyze the transfer of sialic acid from cytidine 5-prime monophospho-N-acetylneuraminic acid (CMP-NeuAc) to terminal positions of glycoprotein and glycolipid carbohydrate groups. Terminal NeuAc residues are key determinants of carbohydrate structures, such as the sialyl-Lewis X determinants, and are widely distributed in many cell types. However, cancer cells often express more heavily sialylated glycans on their cell surface and this feature sometimes correlates with invasiveness. In contrast, expression of ST3gal6, a member of the sialyltransferase family that sialylates type II lactosamine structures on glycoproteins and glycolipids, was found to be significantly decreased by hypermethylation of the gene in gastrointestinal cancer. At least three isoforms of ST3gal6 are known to exist.

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203