Bio-Connect
Western blot analysis of extracts from Jurkat cells, COLO205 cells and HUVEC cells, using STAT1 antibody.
Western blot analysis of extracts from Jurkat cells, COLO205 cells and HUVEC cells, using STAT1 antibody.
Western blot analysis of extracts from Jurkat cells, COLO205 cells and HUVEC cells, using STAT1 antibody.

STAT1 Antibody

CSB-PA697883
Cusabio
TargetSTAT1
Product group Antibodies
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Cusabio
  • Product Name
    STAT1 Antibody
  • Delivery Days Customer
    20
  • Formulation
    Liquid
  • Gene ID6772
  • Target name
    STAT1
  • Target description
    signal transducer and activator of transcription 1
  • Target synonyms
    CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1-alpha/beta; STAT91; transcription factor ISGF-3 components p91/p84
  • Protein IDP42224
  • Protein Name
    Signal transducer and activator of transcription 1-alpha/beta
  • Scientific Description
    Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Schindler C., Proc. Natl. Acad. Sci. U.S.A. 89:7836-7839(1992). Hillier L.W., Nature 434:724-731(2005). Yan R., Nucleic Acids Res. 23:459-463(1995).
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203