STAT2 Antibody, Biotin conjugated

Cusabio

STAT2 Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

STAT2

signal transducer and activator of transcription 2

IMD44; interferon alpha induced transcriptional activator; ISGF-3; P113; PTORCH3; signal transducer and activator of transcription 2; signal transducer and activator of transcription 2, 113kDa; STAT113

Rabbit

IgG

Signal transducer and activator of transcription 2

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Human

-20°C or -80°C

12352203