STAT3-IN-18
HY-155808
Overview
- SupplierMedChem Express
- Product NameSTAT3-IN-18
- Delivery Days Customer14
- CertificationResearch Use Only
- Molecular FormulaC18H24Cl2N2O6Pt
- Molecular Weight630.38
- Scientific DescriptionSTAT3-IN-18 (compound SPP) is a platinum (IV) complex with an axial ligand derived from sandalwood. STAT3-IN-18 inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, with anti-proliferative activity. STAT3-IN-18 activates caspase-3 and increases cleaved polyADP-ribose polymerase to induce apoptosis. STAT3-IN-18 promotes maturation and antigen presentation of dendritic cells and demonstrates safety in vivo.
- SMILES[Cl-][Pt+4]([Cl-])([NH3])([NH3])([OH-])[O-]C(COC(C=C1)=CC=C1/C=C/C2=CC(OC)=CC(OC)=C2)=O
- UNSPSC12352200