STAT3-IN-20

MedChem Express

STAT3-IN-20

5

Research Use Only

99.83

C30H27F4N7S

593.64

STAT3-IN-20 (Compound 40) is a selective STAT3 inhibitor (IC50: 0.65 microM). STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells (IC50: 2.97 microM and 3.26 microM respectively). STAT3-IN-20 induces cell cycle arrest and apoptosis[1].

FC1=CC=C(C2=NC3=CC(NC4=NN=C(S4)C5=CC=C(C=C5)C(F)(F)F)=C(C=C3N2C6CC6)N7CCN(CC7)C)C=C1

-20°C,2°C to 8°C

12352200