STAT3-IN-27

MedChem Express

STAT3-IN-27

5

Research Use Only

C18H21N3O4S

375.44

STAT3-IN-27 (Compound 41) is an orally active inhibitor for phosphorylation of STAT3 (KD is 4.4 microM) and STAT3 transcription (IC50 is 22.57 nM). STAT3-IN-27 inhibits proliferation of various cancer cells with IC50 of 10-500 nM. STAT3-IN-27 arrests the cell cycle at G2/M phase, induces mitochondrial dysfunction and apoptosis in HCT116, inhibits cell migration of HCT116. STAT3-IN-27 exhibits antitumor efficacy in mouse model[1].

O=C(C1C2ON=C1C)C3=C(C=C(C(NCCCN4CCCC4)=O)S3)C2=O

12352200