STAT3-IN-32

MedChem Express

STAT3-IN-32

9

Research Use Only

C36H32F3N7O5

699.68

STAT3-IN-32 (compound 2p) is an orally active, potent STAT3 dual phosphorylation inhibitor with an indole-containing tetra-aromatic heterocycle scaffold. STAT3-IN-32 exhibits STAT3 luciferase inhibition activity using HEK293T cells with an IC50 of 5.3 nM and ATP production inhibition activity using BxPC-3 cells with an IC50 of 4.2 nM. STAT3-IN-32 significantly blocks p-Tyr705 and p-Ser727 and causes the abrogation of the corresponding nuclear transcription and mitochondrial oxidative phosphorylation functions of STAT3 by targeting the STAT3 SH2 domain (KD=21.3 nM). STAT3-IN-32 exhibits significant suppressive effects in a pancreatic cancer xenograft model[1].

O=C(C(N1C)=CC2=C1C=C(OC3=NC=C(C4=NC(C5=CC=C(OC)C=C5)=NO4)N=C3)C=C2)N6CCN(CC7=CC=C(OCC(F)(F)F)C=C7)CC6

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