STAT3/HDAC-IN-2

MedChem Express

STAT3/HDAC-IN-2

9

Research Use Only

C28H32N2O7

508.56

STAT3/HDAC-IN-2 (compound 18) is a dual inhibitor of STAT3 and HDAC, inducing autophagy and apoptosis. STAT3/HDAC-IN-2 is an amphiphilic hydroxamic acid hybrid based on the natural product isopropanol lactone (IAL) and is a nanoscale anticancer agent. STAT3/HDAC-IN-2 can self-assemble in water to form nanoparticles, which have higher tumor tissue accumulation, cellular uptake and anticancer properties compared to the free state[1].

O=C(NO)/C=C/C1=CC=C(C(N[C@H](C)C(O[C@H]2C([C@@](C[C@@](C(C(O3)=O)=C)([H])[C@@]3([H])C4)([H])[C@]4(C)CC2)=C)=O)=O)C=C1

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