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ProductsBack/Stevioside hydrate [57817-89-7]
Chemical Structure
Chemical Structure
Chemical Structure

Stevioside hydrate [57817-89-7]

Research Use Only
AG-CN2-0077
AdipoGen Life Sciences
CAS Number57817-89-7
DownloadMSDS
Product group Chemicals
Estimated Purity>95%
Molecular Weight804.9 (anhydrous basis)
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Stevioside . hydrate [57817-89-7]
  • Delivery Days Customer
    10
  • CAS Number
    57817-89-7
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C38H60O18 . xH2O
  • Molecular Weight
    804.9 (anhydrous basis)
  • Scientific Description
    Chemical. CAS: 57817-89-7 (anhydrous). Formula: C38H60O18 . xH2O. MW: 804.9 (anhydrous basis). Isolated from Stevia rebaudiana. Noncaloric natural sweetener, 300 times more potent than sucrose. Antidiabetic. Antihyperglycaemic and antihypoglycaemic. Potentiates insulin secretion. Enhances acetyl-CoA carboxylase (ACC) gene expression. Increases insulin sensitivity. Antihypertensive. Ca2+ influx inhibitor. Anticancer compound. Chemopreventive. Anti-inflammatory. IKKbeta, NF-kappaB and MAPK signaling inhibitor. Induces TNF-alpha, IL-1beta and nitric oxide release. Immunomodulator. Increasees phagocytic activity, haemagglutination antibody titre, delayed type hypersensitivity. Increased proliferation in LPS and Con A stimulated B and T cells. Peripheral micro-opioid receptors activator. Important for regulation of glucose homeostasis. Anti-atherosclerotic. Review. - Noncaloric natural sweetener, 300 times more potent than sucrose [1]. Antidiabetic. Antihyperglycaemic and antihypoglycaemic. Potentiates insulin secretion. Enhances acetyl-CoA carboxylase (ACC) gene expression. Increases insulin sensitivity. [2, 4, 6-9, 11]. Antihypertensive. Ca2+ influx inhibitor [3, 6]. Anticancer compound [5]. Chemopreventive [14]. Anti-inflammatory. IKKbeta, NF-kappaB and MAPK signaling inhibitor. Induces TNF-alpha, IL-1beta and nitric oxide release [10, 17, 18]. Immunomodulator. Increasees phagocytic activity, haemagglutination antibody titre, delayed type hypersensitivity. Increased proliferation in LPS and Con A stimulated B and T cells [12]. Peripheral micro-opioid receptors activator. Important for regulation of glucose homeostasis [15]. Anti-atherosclerotic [16]. Review [13].
  • SMILES
    [H][C@@]12CC[C@@]3(C[C@]1(CC3=C)CC[C@]1([H])[C@@](C)(CCC[C@@]21C)C(=O)O[C@@H]1OC(CO)[C@@H](O)[C@@H](O)C1O)O[C@@H]1OC(CO)[C@@H](O)[C@@H](O)C1O[C@@H]1OC(CO)[C@@H](O)[C@@H](O)C1O
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200

References

  • Letter to the editor: stevioside, a natural sweetening agent: C. Taylor; Am. J. Clin. Nutr. 22, 4 (1969)
  • Stevioside acts directly on pancreatic beta cells to secrete insulin: actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity: P.B. Jeppesen, et al.; Metabolism 49, 208 (2000)
  • Inhibitory effect of stevioside on calcium influx to produce antihypertension: C.N. Lee, et al.; Planta Med. 67, 796 (2001)
  • Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats: P.B. Jeppesen, et al.; Phytomedicine 9, 9 (2002)
  • Inhibitory effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin: K. Yasukawa, et al.; Biol. Pharm. Bull. 25, 1488 (2002)
  • Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat: P.B. Jeppesen, et al.; Metabolism 52, 372 (2003)
  • Antihyperglycemic effects of stevioside in type 2 diabetic subjects: S. Gregersen, et al.; Metabolism 53, 73 (2004)
  • Effects of stevioside on glucose transport activity in insulin-sensitive and insulin-resistant rat skeletal muscle: N. Lailerd, et al.; Metabolism 53, 101 (2004)
  • Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana: T.H. Chen, et al.; Planta Med. 71, 108 (2005)
  • Anti-Inflammatory and Immunomodulatory Activities of Stevioside and Its Metabolite Steviol on THP-1 Cells: C. Boonkaewwan, et al.; J. Agric. Food Chem. 54, 785 (2006)