STL127705

MedChem Express

STL127705 [1326852-06-5]

10

1326852-06-5

Research Use Only

98.0

C22H20FN5O4

437.42

STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor with an IC 50 of 3.5 microM. STL127705 interferes the binding of Ku70/80 to DNA and by inhibits the activation of the DNA-PKCS kinase. STL127705 shows antiproliferative and anticancer activity. STL127705 induces apoptosis [1] [2] .

O=C1NC2=NC(NCCC3=CC=C(OC)C(OC)=C3)=NC=C2C(N1C4=CC=CC(F)=C4)=O

-20°C,2°C to 8°C

12352200