Sunitinib-d4

MedChem Express

Sunitinib-d4 [1126721-79-6]

10

1126721-79-6

Research Use Only

C22H23D4FN4O2

402.50

Sunitinib-d 4 is the deuterium labeled Sunitinib. Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRbeta, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1alpha by inhibiting autophosphorylation and consequent RNase activation[2].

C(=C\1/C=2C(NC1=O)=CC=C(F)C2)\C3=C(C)C(C(NC(C(N(CC)CC)([2H])[2H])([2H])[2H])=O)=C(C)N3

12352200