![Superoxide Dismutase 1 (SOD1) (Antioxidant Enzyme) (SOD1/2089), CF405S conjugate, 0.1mg/mL [26628-22-8] Superoxide Dismutase 1 (SOD1) (Antioxidant Enzyme) (SOD1/2089), CF405S conjugate, 0.1mg/mL [26628-22-8]](https://biotium.com/wp-content/uploads/2018/10/BNUB2089.jpeg)
Superoxide Dismutase 1 (SOD1) (Antioxidant Enzyme) (SOD1/2089), CF405S conjugate, 0.1mg/mL [26628-22-8]
BNC042089
ReactivityBovine, Human, Mouse
Product group Antibodies
TargetSOD1
Overview
- SupplierBiotium
- Product NameSuperoxide Dismutase 1 (SOD1) (Antioxidant Enzyme) (SOD1/2089), CF405S conjugate, 0.1mg/mL
- Delivery Days Customer9
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDSOD1/2089
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID6647
- Target nameSOD1
- Target descriptionsuperoxide dismutase 1
- Target synonymsALS; ALS1; Cu/Zn superoxide dismutase; epididymis secretory protein Li 44; HEL-S-44; homodimer; hSod1; indophenoloxidase A; IPOA; SOD; SOD, soluble; STAHP; superoxide dismutase [Cu-Zn]; superoxide dismutase 1, soluble; superoxide dismutase, cystolic
- HostMouse
- IsotypeIgG
- Protein IDP00441
- Protein NameSuperoxide dismutase [Cu-Zn]
- Scientific DescriptionCu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityBovine, Human, Mouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203