SUPT16H Antibody, Biotin conjugated

Cusabio

SUPT16H Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

SUPT16H

SPT16 homolog, facilitates chromatin remodeling subunit

CDC68; chromatin-specific transcription elongation factor 140 kDa subunit; facilitates chromatin remodeling 140 kDa subunit; facilitates chromatin transcription complex subunit SPT16; FACT 140 kDa subunit; FACT complex subunit SPT16; FACTP140; hSPT16; NEDDFAC; SPT16; SPT16/CDC68; suppressor of Ty 16 homolog

Rabbit

IgG

FACT complex subunit SPT16

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of \Ser-392\ of p53/TP53 via its association with CK2 (casein kinase II).

Human

-20°C or -80°C

12352203