Sutetinib [1259519-20-4]

TargetMol Chemicals

Sutetinib [1259519-20-4]

9

Research Use Only

C26H25N5O2

439.51

Sutetinib is an orally effective tyrosine kinase inhibitor that targets enzymes linked to tumor growth and angiogenesis, such as VEGFR (VEGFR-1/2/3 with Ki= 0.009 microM), PDGFR (PDGFR-alpha/beta with Ki= 0.008 microM), and the proto-oncogene cKIT. It inhibits the proliferation, migration, and tubular structure formation of endothelial and fibroblast cells, demonstrating antitumor activity across various cancer cell lines.

N(C=1C2=C(C=C(OCC)C(NC(/C=C/CN(C)C)=O)=C2)N=CC1C#N)C3=CC(C#C)=CC=C3

-20°C

12352200