SynGAP antibody

GeneTex

SynGAP antibody

9

WB: 1 microg/ml. ICC/IF: 2 microg/ml. IHC-P: 1:100. FACS: 3-5 microg/106 cells. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Syngap1

synaptic Ras GTPase activating protein 1 homolog (rat)

Gm1963; neuronal RasGAP; ras GTPase-activating protein SynGAP; ras/Rap GTPase-activating protein SynGAP; Sy; synaptic Ras GTPase-activating protein 1; synaptic Ras-GAP 1; Syngap

Rabbit

IgG

Ras/Rap GTPase-activating protein SynGAP

This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Homozygous mutations result in early post-embryonic lethality, while heterozygous mutant mice display a variety of phenotypes that include learning and memory defects, hyperactivity, and audiogenic seizures. [provided by RefSeq, Nov 2016]

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203