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ProductsBack/T-2 Toxin [21259-20-1]
Chemical Structure
Chemical Structure
Chemical Structure

T-2 Toxin [21259-20-1]

Research Use Only
AG-CN2-0473
AdipoGen Life Sciences
CAS Number21259-20-1
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight466.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    T-2 Toxin [21259-20-1]
  • Delivery Days Customer
    10
  • ADR Class
    6.1
  • CAS Number
    21259-20-1
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Danger,Excepted quantity
  • Molecular Formula
    C24H34O9
  • Molecular Weight
    466.5
  • Scientific Description
    Chemical. CAS: 21259-20-1. Formula: C24H34O9. MW: 466.5. Isolated from fungus Fusarium tricinctum. Common trichothecene mycotoxin, which can infect grain crops causing alimentary toxic aleukia in humans and animals. Inhibits DNA and RNA synthesis in vivo and in vitro and can induce apoptosis. In vivo the compound rapidly metabolizes to HT-2 mycotoxin (a major metabolite). Inhibits protein synthesis through its high binding affinity to peptidyl transferase, which is an integral part of the 60S ribosomal subunit, resulting in activation of JNK/p38 MAPKs. Interferes with the metabolism of membrane phospholipids and increases liver lipid peroxides. Increases blood-brain barrier permeability and inhibits monoamine oxidase activity in brain. Reactive oxygen species (ROS) inducer. - Common trichothecene mycotoxin, which can infect grain crops causing alimentary toxic aleukia in humans and animals. Inhibits DNA and RNA synthesis in vivo and in vitro and can induce apoptosis. In vivo the compound rapidly metabolizes to HT-2 mycotoxin (a major metabolite). Inhibits protein synthesis through its high binding affinity to peptidyl transferase, which is an integral part of the 60S ribosomal subunit, resulting in activation of JNK/p38 MAPKs. Interferes with the metabolism of membrane phospholipids and increases liver lipid peroxides. Increases blood-brain barrier permeability and inhibits monoamine oxidase activity in brain. Reactive oxygen species (ROS) inducer.
  • SMILES
    [H][C@@]12O[C@]3([H])C=C(C)[C@H](C[C@]3(COC(C)=O)[C@@](C)([C@H](OC(C)=O)[C@H]1O)[C@]21CO1)OC(=O)CC(C)C
  • Storage Instruction
    2°C to 8°C,-20°C
  • UN Number
    UN 3462
  • UNSPSC
    12352200

References

  • The structures of toxins from two strains of Fusarium tricinctum: J.R. Bamburg, et al.; Tetrahedron 24, 3329 (1968)
  • Measurement of the stability of T-2 toxin in aqueous solution: J. Mary, et al.; Chem. Res. Tox. 6, 524 (1993)
  • T-2 toxin-induced apoptosis in lymphoid organs of mice: J. Shinozuka, et al.; Exp. Toxicol. Pathol. 49, 387 (1997)
  • Apoptotic cellular damage in mice after T-2 toxin-induced acute toxicosis: T. Ihara, et al.; Nat. Toxins 5, 141 (1997)
  • T-2 toxin-induced apoptosis in hematopoietic tissues of mice: J. Shinozuka, et al.; Toxicol. Pathol. 26, 674 (1998)
  • Effect of T-2 toxin on blood-brain barrier permeability monoamine oxidase activity and protein synthesis in rats: J. Wang, et al.; Food Chem. Toxicol. 36, 955 (1998)
  • Cytotoxicity and related effects of T-2 toxin on cultured Vero cells: C. Bouaziz, et al.; Toxicon 48, 343 (2006)
  • Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways: K. Doi & K. Uetsuka; Int. J. Mol. Sci. 12, 5213 (2011)
  • T-2 toxin, a trichothecene mycotoxin: review of toxicity, metabolism, and analytical methods: Y. Li, et al.; J. Agric. Food Chem. 59, 3441 (2011)
  • The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in the pig: J. Seeboth, et al.; Vet. Res. 43, 1 (2012)