T-3364366

MedChem Express

T-3364366 [1356354-09-0]

10

1356354-09-0

Research Use Only

99.73

C18H16F3N3O3S2

443.46

T-3364366 is a reversible, slow-binding, thienopyrimidinone delta-5 desaturase ( D5D ) inhibitor with IC 50 s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively. T-3364366 exhibits potent D5D ( IC 50 0=19 nM) inhibitory activity and excellent selectivity away from delta-6 desaturase (D6D, IC 50 =6200 nM) and delta-9 desaturase (stearoyl-CoA desaturase, SCD, 50 >10000 nM) in the enzymatic activity assay [1] .

CC(NCCSC1=NC2=CSC=C2C(N1C3=CC=C(OCC(F)(F)F)C=C3)=O)=O

-20°C,2°C to 8°C

12352200