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TAB1 Polyclonal Antibody

Research Use Only
RD267699A
Reddot Biotech
ApplicationsImmunoFluorescence
Product group Antibodies
ReactivityHuman, Mouse
TargetTAB1
Price on request
Packing Size
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    TAB1 Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    ImmunoFluorescence
  • Certification
    Research Use Only
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID10454
  • Target name
    TAB1
  • Target description
    TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  • Target synonyms
    3'-Tab1; MAP3K7IP1; mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TAK1-binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203