TAB1 Polyclonal Antibody

Reddot Biotech

TAB1 Polyclonal Antibody

5

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.2 mg/ml

Unconjugated

TAB1

TGF-beta activated kinase 1 (MAP3K7) binding protein 1

3'-Tab1; MAP3K7IP1; mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TAK1-binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1

Rabbit

IgG

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1.

Human, Mouse

-20°C

12352203