TAB3 Antibody

Biorbyt

TAB3 Antibody

16

Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.

Western Blot

Western blot: 4-8ug/ml WB

Research Use Only

Polyclonal

Unconjugated

TAB3

TGF-beta activated kinase 1 (MAP3K7) binding protein 3

MAP3K7IP3; mitogen-activated protein kinase kinase kinase 7 interacting protein 3; NAP1; NF-kappa-B-activating protein 1; NFkB activating protein 1; TAB-3; TAK1-binding protein 3; TGF-beta activated kinase 1 and MAP3K7 binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TGF-beta-activated kinase 1-binding protein 3

Rabbit

IgG

TAB3, a TAB2-like protein, is a mediator of TAK1 activation in IL-1 and TNF signaling. IL-1 and TNF are cytokines involved in the inflammation process, initiating signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (MAPKs). TAB3 functions as an adapter, linking TAK1 and TRAF6 or TRAF2. This kinase complex phosphorylates IkB, which keeps NF-kB inactive and sequestered in the cytoplasm. Phosphorylation leads to IkB degradation, activating NF-kB, which translocates to the nucleus, binds to DNA response elements and can begin multiple signaling cascades.

Human, Mouse

-20°C

12352203