TAK-828F

MedChem Express

TAK-828F [1854901-94-2]

10

1854901-94-2

Research Use Only

C28H32FN3O5

509.57

TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor gammat ( RORgammat ) inverse agonist (binding IC 50 =1.9 nM, reporter gene IC 50 =6.1 nM). TAK-828F shows excellent RORgammat isoforms selectivity (>5000-fold selectivity against human RORalpha and RORbeta) [1] .

CC1(C)C2=C(F)C=C(NC([C@@H]3N(C([C@@H]4C[C@H](CC(O)=O)C4)=O)CCC5=C3C=CC(OC)=N5)=O)C=C2CC1

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