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TAK-960

HY-15160
MedChem Express
CAS Number1137868-52-0
Product group Chemicals
Estimated Purity99.75
Molecular Weight561.60
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Overview

  • Supplier
    MedChem Express
  • Product Name
    TAK-960 [1137868-52-0]
  • Delivery Days Customer
    10
  • CAS Number
    1137868-52-0
  • Certification
    Research Use Only
  • Estimated Purity
    99.75
  • Molecular Formula
    C27H34F3N7O3
  • Molecular Weight
    561.60
  • Scientific Description
    TAK-960 is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM. TAK-960 also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. TAK-960 inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts[1].
  • SMILES
    O=C(NC1CCN(C)CC1)C2=CC(OC)=C(NC3=NC=C(N4C)C(N(C5CCCC5)CC(F)(F)C4=O)=N3)C=C2F
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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