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Taminadenant

HY-109139
MedChem Express
CAS Number1337962-47-6
DownloadMSDS
Product group Chemicals
Estimated Purity99.84
Molecular Weight306.12
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Taminadenant [1337962-47-6]
  • Delivery Days Customer
    10
  • CAS Number
    1337962-47-6
  • Certification
    Research Use Only
  • Estimated Purity
    99.84
  • Molecular Formula
    C10H8BrN7
  • Molecular Weight
    306.12
  • Scientific Description
    Taminadenant (NIR178; PBF509) is a highly potent and orally active adenosine A 2A receptor (A 2A R) antagonist. Taminadenant can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with K B values of 72.8 nM and 8.2 nM, respectively. Taminadenant reverses motor impairments in several rat models of movement disorders, including catalepsy, tremor, and hemiparkinsonism. Taminadenant can also inhibit tumor growth when combined with Spartalizumab (HY-P9972). Taminadenant reactivate the antitumor immune response [1] [2] .
  • SMILES
    BrC(C(N1C=CC=N1)=NC(N2C=CC=N2)=N3)=C3N
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200