TAT-cyclo-CLLFVY [1446322-66-2]

TargetMol Chemicals

TAT-cyclo-CLLFVY [1446322-66-2]

44

1446322-66-2

Chemical

Research Use Only

TAT-cyclo-CLLFVY

C111H188N42O24S2

2559.1

Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1alpha, but not HIF-2alpha, with HIF-1beta (IC50 = 1.3 microM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.

3 years

C(=O)([C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CSSC[C@@H]2NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H]([C@@H](C)C)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC2=O)N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCCN)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC1)N5[C@H](C(N[C@@H](CCC(N)=O)C(O)=O)=O)CCC5

-20°C

12352200