IHC-P analysis of human brain tissue using GTX86147 Tau (phospho Ser422) antibody. The picture on the right is blocked with the synthesized peptide.
IHC-P analysis of human brain tissue using GTX86147 Tau (phospho Ser422) antibody. The picture on the right is blocked with the synthesized peptide.
Tau (phospho Ser422) antibody
GTX86147
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetMAPT
Overview
- SupplierGeneTex
- Product NameTau (phospho Ser422) antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500~1:1000. IHC-P: 1:50~1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID4137
- Target nameMAPT
- Target descriptionmicrotubule associated protein tau
- Target synonymsDDPAC; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPTL; microtubule-associated protein tau; MSTD; MTBT1; MTBT2; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; TAU; tau-40
- HostRabbit
- IsotypeIgG
- Protein IDP10636
- Protein NameMicrotubule-associated protein tau
- Scientific DescriptionThis gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimers disease, Picks disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau. Polanco JC et al., 2023 Jan, Life Sci AllianceRead more
- An App knock-in rat model for Alzheimers disease exhibiting Abeta and tau pathologies, neuronal death and cognitive impairments. Pang K et al., 2022 Feb, Cell ResRead more
- Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice. Bajracharya R et al., 2021 Mar 12, Acta Neuropathol CommunRead more
- Temporal and regional progression of Alzheimers disease-like pathology in 3xTg-AD mice. Belfiore R et al., 2019 Feb, Aging CellRead more
- Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model. Bodea LG et al., 2017 Apr, Aging CellRead more
- A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions. Baker S et al., 2016 Mar 31, Acta Neuropathol CommunRead more
- Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner. Polanco JC et al., 2016 Jun 10, J Biol ChemRead more