TBK1/IKKε-IN-1(compound 1) [1893397-65-3]

Selleck Chemicals

TBK1/IKKε-IN-1(compound 1) [1893397-65-3]

9

Research Use Only

TBK1/IKKepsilon-IN-1 (compound 1) is a dual inhibitor of TANK-binding kinase 1 (TBK1) and IkappaB kinase-epsilon (IKKepsilon/IKK-i) with IC50 of 1.0 nM and 5.6 nM for TBK1 and IKKepsilon, respectively. TBK1/IKKepsilon inhibition enhances response to PD-1 blockade, which effectively predicts tumor response in vivo.

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