TC-E 5008

MedChem Express

TC-E 5008 [50405-58-8]

10

50405-58-8

Research Use Only

C13H13NO2

215.25

TC-E 5008 is a potent mutant IDH1 inhibitor with K i values of 190 nM and 120 nM for R132H and R132C IDH1 mutants, respectively. TC-E 5008 exhibits very weak activity against WT-IDH1 with a K i value of 12.3 microM. TC-E 5008 has anti-proliferative activity on multiple ER positive breast cancer cell lines [1] [2] .

ON1C(CC2=CC=CC=C2)=CC(C)=CC1=O

12352200