TC-I 2014

MedChem Express

TC-I 2014 [1221349-53-6]

10

1221349-53-6

Research Use Only

99.0

C23H19F6N3O

467.41

TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC 50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models [1] .

FC(C1=CC=CC=C1C2=CC(C(F)(F)F)=C3C(N=C(C4=NOC5(CCCCC5)C4)N3)=C2)(F)F

-20°C,2°C to 8°C

12352200