TCF7 Polyclonal Antibody

Reddot Biotech

TCF7 Polyclonal Antibody

5

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.78 mg/ml

Unconjugated

TCF7

transcription factor 7

T-cell-factor-7; T-cell-specific transcription factor 1; TCF-1; transcription factor 7; transcription factor 7 (T-cell specific, HMG-box)

Rabbit

IgG

This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling.

Human, Mouse

-20°C

12352203