TDP1 Polyclonal Antibody
RD267936A
ApplicationsImmunoFluorescence
Product group Antibodies
ReactivityHuman
TargetTDP1
Overview
- SupplierReddot Biotech
- Product NameTDP1 Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsImmunoFluorescence
- CertificationResearch Use Only
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID55775
- Target nameTDP1
- Target descriptiontyrosyl-DNA phosphodiesterase 1
- Target synonymstyr-DNA phosphodiesterase 1; tyrosyl-DNA phosphodiesterase 1
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1).
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203