TDP2 / EAPII (TDP2/1258), CF405S conjugate, 0.1mg/mL [26628-22-8]
BNC041258
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetTDP2
Overview
- SupplierBiotium
- Product NameTDP2 / EAPII (TDP2/1258), CF405S conjugate, 0.1mg/mL
- Delivery Days Customer9
- ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDTDP2/1258
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID51567
- Target nameTDP2
- Target descriptiontyrosyl-DNA phosphodiesterase 2
- Target synonyms5'-Tyr-DNA phosphodiesterase; 5'-tyrosyl-DNA phosphodiesterase; AD022; dJ30M3.3; EAP2; EAPII; epididymis secretory sperm binding protein; ETS1-associated protein 2; ETS1-associated protein II; hTDP2; TRAF and TNF receptor-associated protein; TTRAP; tyr-DNA phosphodiesterase 2; tyrosyl-DNA phosphodiesterase 2; tyrosyl-RNA phosphodiesterase; VPg unlinkase
- HostMouse
- IsotypeIgG2b
- Scientific DescriptionThis MAb recognizes a protein of 41 kDa, which is identified as TDP2. It is a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5-phosphodiester bond, giving rise to DNA with a free 5 phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5-phosphoglycolates on protruding 5 ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a clean DSB with 5-phosphate termini that are ready for ligation. Has also 3-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityBovine, Human, Mouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203