TEAD3 Antibody

Cusabio

TEAD3 Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

TEAD3

TEA domain transcription factor 3

DTEF-1; ETFR-1; TEA domain family member 3; TEA domain family member 5; TEAD-3; TEAD5; TEF5; TEF-5; transcriptional enhancer factor 5; transcriptional enhancer factor TEF-5; transcriptional enhancer factor TEF-5 (DTEF-1)

Rabbit

IgG

Transcriptional enhancer factor TEF-5

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. Jacquemin P., J. Biol. Chem. 272:12928-12937(1997). Mungall A.J., Nature 425:805-811(2003). Zhao B., Genes Dev. 22:1962-1971(2008).

Human

-20°C or -80°C

12352203