TEAD3 Antibody
CSB-PA904251
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
Overview
- SupplierCusabio
- Product NameTEAD3 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- HostRabbit
- IsotypeIgG
- Scientific DescriptionTranscription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. Jacquemin P., J. Biol. Chem. 272:12928-12937(1997). Mungall A.J., Nature 425:805-811(2003). Zhao B., Genes Dev. 22:1962-1971(2008).
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203