TEAD4 Antibody, FITC conjugated
CSB-PA618010LC01HU
ReactivityHuman
Product group Antibodies
Overview
- SupplierCusabio
- Product NameTEAD4 Antibody, FITC conjugated
- Delivery Days Customer20
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateFITC
- HostRabbit
- IsotypeIgG
- Scientific DescriptionTranscription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC \enhansons\ (5\-GTGGAATGT-3\) and activates transcription. Binds to the M-CAT motif.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203