Terrecyclic Acid

MedChem Express

Terrecyclic Acid [83058-94-0]

5

83058-94-0

Research Use Only

C15H20O3

248.32

Terrecyclic acid is a sesquiterpene originally isolated from A. terreus with antibiotic and anticancer activity. It is active against S. aureus, B. subtilis, and M. roseus (MICs=25, 50, and 25 microg/mL, respectively). Terrecyclic acid induces a heat shock response, increases levels of reactive oxygen species (ROS), and inhibits NF-kappaB activity and cell growth in 3T3-Y9-B12 cells.2 In vivo, terrecyclic acid (0.1, 1, and 10 mg/ml) reduces the number of ascitic fluid tumor cells in a mouse model of P388 murine leukemia.

OC([C@H](CC1)[C@@](C2)(C3=C)[C@@](CC3=O)([H])[C@]1([H])C2(C)C)=O

12352200