TET1 antibody [N1], N-term

GeneTex

TET1 antibody [N1], N-term

9

WB: 1:500-1:20000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Tet1

tet methylcytosine dioxygenase 1

2510010B09Rik, Cxxc6, D10Ertd17e, LCX, mKIAA1676, methylcytosine dioxygenase TET1, CXXC finger 6, CXXC-type zinc finger protein 6, ten-eleven translocation 1 gene protein homolog, tet oncogene 1

Rabbit

IgG

Methylcytosine dioxygenase TET1

Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.

Mouse

-20°C or -80°C,2°C to 8°C

12352203