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ProductsBack/TET1 antibody [N1], N-term

TET1 antibody [N1], N-term

GTX125888
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityMouse
TargetTet1
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Overview

  • Supplier
    GeneTex
  • Product Name
    TET1 antibody [N1], N-term - KO/KD Validated
  • Delivery Days Customer
    9
  • Antibody Specificity
    Knockdown/Knockout validation was supported by references (PMID: 29513657)
  • Application Supplier Note
    WB: 1:500-1:20000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID52463
  • Target name
    Tet1
  • Target description
    tet methylcytosine dioxygenase 1
  • Target synonyms
    2510010B09Rik; AA517754; BB001228; CXXC finger 6; Cxxc6; CXXC-type zinc finger protein 6; D10Ertd17; D10Ertd17e; LCX; methylcytosine dioxygenase TET1; mKIAA1676; ten-eleven translocation 1 gene protein homolog; tet oncogene 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ3URK3
  • Protein Name
    Methylcytosine dioxygenase TET1
  • Scientific Description
    Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.
  • Reactivity
    Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Tet2 regulates Sin3a recruitment at active enhancers in embryonic stem cells.
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  • Dual functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation.
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  • ZFP281 coordinates DNMT3 and TET1 for transcriptional and epigenetic control in pluripotent state transitions.
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  • A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency. Huang X et al., 2022 Jun 7, Cell Rep
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  • Tet1 Suppresses p21 to Ensure Proper Cell Cycle Progression in Embryonic Stem Cells. Chrysanthou S et al., 2022 Apr 17, Cells
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  • The DNA dioxygenase Tet1 regulates H3K27 modification and embryonic stem cell biology independent of its catalytic activity. Chrysanthou S et al., 2022 Apr 8, Nucleic Acids Res
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  • Tet enzymes are essential for early embryogenesis and completion of embryonic genome activation. Arand J et al., 2022 Feb 3, EMBO Rep
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  • The chromosomal protein SMCHD1 regulates DNA methylation and the 2c-like state of embryonic stem cells by antagonizing TET proteins. Huang Z et al., 2021 Jan, Sci Adv
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  • Reprogramming competence of OCT factors is determined by transactivation domains. Kim KP et al., 2020 Sep, Sci Adv
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  • TET1 and 5-Hydroxymethylation Preserve the Stem Cell State of Mouse Trophoblast. Senner CE et al., 2020 Dec 8, Stem Cell Reports
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