Tetrahydroxystilbene-2-O-beta-D-glucoside [55327-45-2]

TargetMol Chemicals

Tetrahydroxystilbene-2-O-beta-D-glucoside [55327-45-2]

4

55327-45-2

Chemical

Research Use Only

Tetrahydroxystilbene-2-O-bèta-D-glucoside

99.47%

C20H22O9

406.38

Tetrahydroxystilbene-2-O-beta-D-glucoside (EH-201) is a low MW inducer of erythropoietin. Tetrahydroxystilbene-2-O-beta-D-glucoside induces expression of erythropoietin, PPAR-gamma coactivator 1alpha (PGC-1alpha) and haemoglobin in astrocytes and PC12 neuronal-like cells. In vivo, Tetrahydroxystilbene-2-O-beta-D-glucoside treatment restores memory impairment, as assessed by the passive avoidance test, in SD, Abeta and KA mouse models. In the hippocampus of mice given Tetrahydroxystilbene-2-O-beta-D-glucoside in their diet, levels of erythropoietin, PGC-1alpha and haemoglobin were increased. Treatment with Tetrahydroxystilbene-2-O-beta-D-glucoside might be a therapeutic strategy for memory impairment in neurodegenerative disease, physiological ageing or traumatic brain injury.

3 years

O(C1=C(C=CC2=CC=C(O)C=C2)C=C(O)C=C1O)[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O

-20°C

12352200