TH-Z827 [2847881-81-4]

TargetMol Chemicals

TH-Z827 [2847881-81-4]

16

Chemical

Research Use Only

TH-Z827

C30H38N6O

498.66

TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 microM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C). Additionally, it disrupts the KRAS(G12D)-CRAF interaction with an IC50 of 42 microM [1].

3 years

O(C[C@H]1N(C)CCC1)C2=NC(=C3C(CN(CC3)C=4C5=C(C=CC4)C=CC=C5C)=N2)N6C7CCC6CNC7

-20°C

12352200