TH-Z827

MedChem Express

TH-Z827

14

Research Use Only

C30H38N6O

498.66

TH-Z827 is a mutant selective KRAS(G12D) inhibitor with an IC50 of 2.4 microM. TH-Z827 does not bind KRAS(WT) or KRAS(G12C). TH-Z827 blocked the KRAS(G12D)-CRAF interaction with an IC50 value of 42 microM[1].

CN(CCC1)[C@@H]1COC2=NC(N3[C@@H]4CNC[C@H]3CC4)=C5C(CN(C6=CC=CC7=C6C(C)=CC=C7)CC5)=N2

12352200