TH1760 [2567914-01-4]

TargetMol Chemicals

TH1760 [2567914-01-4]

4

Chemical

Research Use Only

TH1760

0.9703

C20H18N4O5S

426.45

TH1760 (MKB) is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM). TH1760 can sensitize cells to 6-thioguanine by increasing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 can enhance the anti-leukemia effect of thiopurine.

3 years

S(=O)(=O)(C=1C=C2C(=CC1)NC(=O)O2)N3CCN(C(=O)C=4C=C5C(=CC4)NC=C5)CC3

-20°C

12352200