Thalidomide-4-O-CH2-COO(t-Bu)
HY-42771
Product group Molecular Biology
Overview
- SupplierMedChem Express
- Product NameThalidomide-4-O-CH2-COO(t-Bu)
- Delivery Days Customer5
- Scientific DescriptionThalidomide-4-O-CH2-COO(t-Bu) is t-Bu modified Thalidomide (HY-14658), which is the final step intermediate in the synthesis of Thalidomide-4-OH (HY-123096). Thalidomide-4-O-CH2-COO(t-Bu) acts as a Cereblon ligand to recruit CRBN proteins. The t-Bu protecting group at the end of Thalidomide-4-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules.
- UNSPSC41116133