Thalidomide-O-C5-azide

MedChem Express

Thalidomide-O-C5-azide

14

Research Use Only

Thalidomide-O-C5-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C5-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C5-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates ( E3 Ligase Ligand-Linker Conjugates ) for the synthesis of PROTACs [1] .

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