Theliatinib (tartrate)

MedChem Express

Theliatinib (tartrate)

10

Research Use Only

C29H32N6O8

592.60

Theliatinib (Xiliertinib) tartrate is a potent, ATP-competitive, orally active and highly selective EGFR inhibitor with a K i of 0.05 nM and an IC 50 of 3 nM. Theliatinib has an IC 50 of 22 nM for EGFR T790M/L858R mutant . Theliatinib shows >50-fold selectivity for EGFR than other kinases [1] . Theliatinib (tartrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

O=C(N1C[C@]2([H])N(C)CC[C@]2([H])C1)NC3=CC4=C(NC5=CC=CC(C#C)=C5)N=CN=C4C=C3OC.OC([C@H](O)[C@@H](O)C(O)=O)=O

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