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ProductsBack/Thermorubin [37577-75-6]
Chemical Structure
Chemical Structure
Chemical Structure

Thermorubin [37577-75-6]

Research Use Only
AG-CN2-0339
AdipoGen Life Sciences
CAS Number37577-75-6
DownloadMSDS
Product group Chemicals
Estimated Purity>85%
Molecular Weight600.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Thermorubin [37577-75-6]
  • Delivery Days Customer
    10
  • CAS Number
    37577-75-6
  • Certification
    Research Use Only
  • Estimated Purity
    >85%
  • Molecular Formula
    C32H24O12
  • Molecular Weight
    600.5
  • Scientific Description
    Anthracene antibiotic. Antibacterial agent. Active against both Gram-positive and Gram-negative bacteria. Inhibits the initiation stage of bacterial protein synthesis by binding to the inter-subunit bridge B2a on the 70S ribosome. Does not inhibit DNA and RNA synthesis. Potent aldose reductase inhibitor. - Chemical. CAS: 37577-75-6. Formula: C32H24O12. MW: 600.5. Isolated from Thermoactinomyces sp. Anthracene antibiotic. Antibacterial agent. Active against both Gram-positive and Gram-negative bacteria. Inhibits the initiation stage of bacterial protein synthesis by binding to the inter-subunit bridge B2a on the 70S ribosome. Does not inhibit DNA and RNA synthesis. Potent aldose reductase inhibitor.
  • SMILES
    O=C1OC(C(OC)=O)=CC2=C1C(O)=C(C(OC)=C(C(OC)=C(C(/C=C(O)/C3=C(O)C=CC=C3)=O)C(CC(O)=O)=C4)C4=C5)C5=C2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Structure of thermorubin A, the major orange-red antibiotic of Thermoactinomyces antibioticus: C.E. Moppett, et al.; JACS 94, 3269 (1972)
  • The protein synthesis inhibitor thermorubin. 1. Nature of the thermorubin-ribosome complex: F. Lin & A. Wishnia; Biochem. 21, 477 (1982)
  • The protein synthesis inhibitor thermorubin. 2. Mechanism of inhibition of initiation on Escherichia coli ribosomes: F. Lin & A. Wishnia; Biochem. 21, 484 (1982)
  • Synthesis and antibacterial activity of some derivatives of the antibiotic thermorubin: B. Cavalleri, et al.; J. Antibiot. 38, 1752 (1985)
  • Thermorubin and 2-hydroxyphenyl acetic acid, aldose reductase inhibitors: K. Hayashi, et al.; J. Antibiot. 48, 1345 (1995)
  • The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge B2a of the ribosome: D. Bulkley, et al.; J. Mol. Biol. 416, 571 (2012)