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Thrombomodulin (recombinant)

Research Use Only
RP_SZ_160
InVivo Biotech
Protein IDP07204
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Product group Proteins / Signaling Molecules
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Overview

  • Supplier
    InVivo Biotech
  • Product Name
    Thrombomodulin (recombinant)
  • Delivery Days Customer
    5
  • Certification
    Research Use Only
  • Concentration
    >= 1.0 mg/ml
  • Formulation
    Liquid
  • Protein IDP07204
  • Protein Name
    Thrombomodulin
  • Scientific Description
    Recombinant form of the extracellular domain of Human Thrombomodulin which is produced under serum-free conditions in HEK 293 (human embryonic kidney) cells. The expression construct contains residues 1 to 515 of UniProt entry P07204: M406L, S492A. The M406L substitution (M388L in the mature protein) leads to a Thrombomodulin variant that resists oxidative inactivation [1]. The S492A substitution (Ser474 in the mature protein) removes an O-glycosylation site for chondroitin sulfate, a glycosaminoglycan (GAG) that increases anticoagulant activity [2, 3]. The recombinant protein is produced under serum-free conditions in optimized HEK293-cell system and purified through one-step purification with ion exchange chromatography.
  • UNSPSC
    12352202