Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (P-GF.44C), CF640R conjugate, 0.1mg/mL [26628-22-8]
BNC401244
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse, Rat
TargetTYMP
Overview
- SupplierBiotium
- Product NameThymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (P-GF.44C), CF640R conjugate, 0.1mg/mL
- Delivery Days Customer9
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDP-GF.44C
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID1890
- Target nameTYMP
- Target descriptionthymidine phosphorylase
- Target synonymsECGF; ECGF1; gliostatin; hPD-ECGF; MEDPS1; MNGIE; MTDPS1; PDECGF; tdRPase; thymidine phosphorylase; TP
- HostMouse
- IsotypeIgG1
- Protein IDP19971
- Protein NameThymidine phosphorylase
- Scientific DescriptionThis antibody recognizes a protein (amino acid 482) of 55 kDa (in vivo 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5 -deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityBovine, Human, Mouse, Rat
- Storage Instruction2°C to 8°C
- UNSPSC12352203