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Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (P-GF.44C), CF640R conjugate, 0.1mg/mL [26628-22-8]

BNC401244
Biotium
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse, Rat
TargetTYMP
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Overview

  • Supplier
    Biotium
  • Product Name
    Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (P-GF.44C), CF640R conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    P-GF.44C
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID1890
  • Target name
    TYMP
  • Target description
    thymidine phosphorylase
  • Target synonyms
    ECGF; ECGF1; gliostatin; hPD-ECGF; MEDPS1; MNGIE; MTDPS1; PDECGF; tdRPase; thymidine phosphorylase; TP
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP19971
  • Protein Name
    Thymidine phosphorylase
  • Scientific Description
    This antibody recognizes a protein (amino acid 482) of 55 kDa (in vivo 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5 -deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse, Rat
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203