Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF594 conjugate, 0.1mg/mL [26628-22-8]

Biotium

Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF594 conjugate, 0.1mg/mL

9

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

TYMP/2890R

0.1 mg/ml

Other Conjugate

TYMP

thymidine phosphorylase

ECGF; ECGF1; gliostatin; hPD-ECGF; MEDPS1; MNGIE; MTDPS1; PDECGF; tdRPase; thymidine phosphorylase; TP

Rabbit

IgG

Thymidine phosphorylase

This antibody recognizes a protein (amino acid 482) of 55 kDa (in vivo 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Bovine, Human, Mouse, Rabbit, Rat

2°C to 8°C

12352203